Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.
Identifieur interne : 000040 ( Main/Exploration ); précédent : 000039; suivant : 000041Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.
Auteurs : Lou Rizzolo [France] ; Marianne Leger [France] ; Sophie Corvaisier [France] ; Mathilde Groussard [France] ; Hervé Platel [France] ; Valentine Bouet [France] ; Pascale Schumann-Bard [France] ; Thomas Freret [France]Source :
- Cerebral cortex (New York, N.Y. : 1991) [ 1460-2199 ] ; 2021.
Abstract
Cognitive decline appears across aging. While some studies report beneficial effects of musical listening and practice on cognitive aging, the underlying neurobiological mechanisms remain unknown. This study aims to determine whether chronic (6 h/day, 3 times/week) and long-lasting (4-8 months) music exposure, initiated at middle age in rats (15 months old), can influence behavioral parameters sensitive to age effects and reduce age-related spatial memory decline in rats. Spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior as well as spatial working and reference memory were assessed in 14-month-old rats and then after 4 and 8 months of music exposure (19 and 23 months old, respectively). Spatial learning and reference memory data were followed up by considering cognitive status of animals prior to music exposure (14 months old) given by K-means clustering of individual Z-score. Hippocampal cell proliferation and brain-derived neurotrophic factor (BDNF) level in the hippocampus and frontal cortex were measured. Results show that music exposure differentially rescues age-related deficits in spatial navigation tasks according to its duration without affecting spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior. Hippocampal cell proliferation as well as hippocampal and frontal cortex BDNF levels was not affected by music across aging. Cognitive improvement by music in aging rats may require distinct neurobiological mechanisms than hippocampal cell proliferation and BDNF.
DOI: 10.1093/cercor/bhaa247
PubMed: 32959057
Affiliations:
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xml:lang="en">Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.</title><author><name sortKey="Rizzolo, Lou" sort="Rizzolo, Lou" uniqKey="Rizzolo L" first="Lou" last="Rizzolo">Lou Rizzolo</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Leger, Marianne" sort="Leger, Marianne" uniqKey="Leger M" first="Marianne" last="Leger">Marianne Leger</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Corvaisier, Sophie" sort="Corvaisier, Sophie" uniqKey="Corvaisier S" first="Sophie" last="Corvaisier">Sophie Corvaisier</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Groussard, Mathilde" sort="Groussard, Mathilde" uniqKey="Groussard M" first="Mathilde" last="Groussard">Mathilde Groussard</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, PSL Research University, EPHE, INSERM U1077, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, PSL Research University, EPHE, INSERM U1077, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>PSL Research University, EPHE, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PSL Research University, EPHE, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Platel, Herve" sort="Platel, Herve" uniqKey="Platel H" first="Hervé" last="Platel">Hervé Platel</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, PSL Research University, EPHE, INSERM U1077, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, PSL Research University, EPHE, INSERM U1077, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>PSL Research University, EPHE, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PSL Research University, EPHE, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bouet, Valentine" sort="Bouet, Valentine" uniqKey="Bouet V" first="Valentine" last="Bouet">Valentine Bouet</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Schumann Bard, Pascale" sort="Schumann Bard, Pascale" uniqKey="Schumann Bard P" first="Pascale" last="Schumann-Bard">Pascale Schumann-Bard</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author><author><name sortKey="Freret, Thomas" sort="Freret, Thomas" uniqKey="Freret T" first="Thomas" last="Freret">Thomas Freret</name><affiliation wicri:level="3"><nlm:affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Basse-Normandie</region><settlement type="city">Caen</settlement></placeName></affiliation></author></analytic><series><title level="j">Cerebral cortex (New York, N.Y. : 1991)</title><idno type="eISSN">1460-2199</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cognitive decline appears across aging. While some studies report beneficial effects of musical listening and practice on cognitive aging, the underlying neurobiological mechanisms remain unknown. This study aims to determine whether chronic (6 h/day, 3 times/week) and long-lasting (4-8 months) music exposure, initiated at middle age in rats (15 months old), can influence behavioral parameters sensitive to age effects and reduce age-related spatial memory decline in rats. Spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior as well as spatial working and reference memory were assessed in 14-month-old rats and then after 4 and 8 months of music exposure (19 and 23 months old, respectively). Spatial learning and reference memory data were followed up by considering cognitive status of animals prior to music exposure (14 months old) given by K-means clustering of individual Z-score. Hippocampal cell proliferation and brain-derived neurotrophic factor (BDNF) level in the hippocampus and frontal cortex were measured. Results show that music exposure differentially rescues age-related deficits in spatial navigation tasks according to its duration without affecting spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior. Hippocampal cell proliferation as well as hippocampal and frontal cortex BDNF levels was not affected by music across aging. Cognitive improvement by music in aging rats may require distinct neurobiological mechanisms than hippocampal cell proliferation and BDNF.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">32959057</PMID><DateRevised><Year>2020</Year><Month>12</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2199</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>1</Issue><PubDate><Year>2021</Year><Month>Jan</Month><Day>01</Day></PubDate></JournalIssue><Title>Cerebral cortex (New York, N.Y. : 1991)</Title><ISOAbbreviation>Cereb Cortex</ISOAbbreviation></Journal><ArticleTitle>Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.</ArticleTitle><Pagination><MedlinePgn>620-634</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/cercor/bhaa247</ELocationID><Abstract><AbstractText>Cognitive decline appears across aging. While some studies report beneficial effects of musical listening and practice on cognitive aging, the underlying neurobiological mechanisms remain unknown. This study aims to determine whether chronic (6 h/day, 3 times/week) and long-lasting (4-8 months) music exposure, initiated at middle age in rats (15 months old), can influence behavioral parameters sensitive to age effects and reduce age-related spatial memory decline in rats. Spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior as well as spatial working and reference memory were assessed in 14-month-old rats and then after 4 and 8 months of music exposure (19 and 23 months old, respectively). Spatial learning and reference memory data were followed up by considering cognitive status of animals prior to music exposure (14 months old) given by K-means clustering of individual Z-score. Hippocampal cell proliferation and brain-derived neurotrophic factor (BDNF) level in the hippocampus and frontal cortex were measured. Results show that music exposure differentially rescues age-related deficits in spatial navigation tasks according to its duration without affecting spontaneous locomotor, circadian rhythmic activity, and anxiety-like behavior. Hippocampal cell proliferation as well as hippocampal and frontal cortex BDNF levels was not affected by music across aging. Cognitive improvement by music in aging rats may require distinct neurobiological mechanisms than hippocampal cell proliferation and BDNF.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rizzolo</LastName><ForeName>Lou</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leger</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Corvaisier</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Groussard</LastName><ForeName>Mathilde</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, PSL Research University, EPHE, INSERM U1077, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>PSL Research University, EPHE, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Platel</LastName><ForeName>Hervé</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, PSL Research University, EPHE, INSERM U1077, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>PSL Research University, EPHE, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouet</LastName><ForeName>Valentine</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schumann-Bard</LastName><ForeName>Pascale</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freret</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Normandie University, Unicaen, INSERM, COMETE, CHU de Caen, Cyceron, 14000 Caen, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cereb Cortex</MedlineTA><NlmUniqueID>9110718</NlmUniqueID><ISSNLinking>1047-3211</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Z-score</Keyword><Keyword MajorTopicYN="N">brain-derived neurotrophic factor</Keyword><Keyword MajorTopicYN="N">hippocampal cell proliferation</Keyword><Keyword MajorTopicYN="N">memory</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>08</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>9</Month><Day>22</Day><Hour>5</Hour><Minute>42</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32959057</ArticleId><ArticleId IdType="pii">5909651</ArticleId><ArticleId IdType="doi">10.1093/cercor/bhaa247</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Région Normandie</li><li>Île-de-France</li></region><settlement><li>Caen</li><li>Paris</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Rizzolo, Lou" sort="Rizzolo, Lou" uniqKey="Rizzolo L" first="Lou" last="Rizzolo">Lou Rizzolo</name></region><name sortKey="Bouet, Valentine" sort="Bouet, Valentine" uniqKey="Bouet V" first="Valentine" last="Bouet">Valentine Bouet</name><name sortKey="Corvaisier, Sophie" sort="Corvaisier, Sophie" uniqKey="Corvaisier S" first="Sophie" last="Corvaisier">Sophie Corvaisier</name><name sortKey="Freret, Thomas" sort="Freret, Thomas" uniqKey="Freret T" first="Thomas" last="Freret">Thomas Freret</name><name sortKey="Groussard, Mathilde" sort="Groussard, Mathilde" uniqKey="Groussard M" first="Mathilde" last="Groussard">Mathilde Groussard</name><name sortKey="Groussard, Mathilde" sort="Groussard, Mathilde" uniqKey="Groussard M" first="Mathilde" last="Groussard">Mathilde Groussard</name><name sortKey="Leger, Marianne" sort="Leger, Marianne" uniqKey="Leger M" first="Marianne" last="Leger">Marianne Leger</name><name sortKey="Platel, Herve" sort="Platel, Herve" uniqKey="Platel H" first="Hervé" last="Platel">Hervé Platel</name><name sortKey="Platel, Herve" sort="Platel, Herve" uniqKey="Platel H" first="Hervé" last="Platel">Hervé Platel</name><name sortKey="Schumann Bard, Pascale" sort="Schumann Bard, Pascale" uniqKey="Schumann Bard P" first="Pascale" last="Schumann-Bard">Pascale 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